{"id":62517,"date":"2026-07-13T11:52:15","date_gmt":"2026-07-13T11:52:15","guid":{"rendered":"https:\/\/www.newscientist.com\/?p=2578806"},"modified":"2026-07-13T11:52:15","modified_gmt":"2026-07-13T11:52:15","slug":"game-that-reduces-dementia-risk-may-clear-amyloid-from-mens-brains","status":"publish","type":"post","link":"https:\/\/hoo.central12.com\/fugic\/2026\/07\/13\/game-that-reduces-dementia-risk-may-clear-amyloid-from-mens-brains\/","title":{"rendered":"Game that reduces dementia risk may clear amyloid from men\u2019s brains"},"content":{"rendered":"\n\n\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1350\" height=\"900\" src=\"https:\/\/www.newscientist.com\/wp-content\/uploads\/2026\/07\/SEI_305085506.jpg\" alt=\"\" class=\"wp-image-2578813\" srcset=\"https:\/\/www.newscientist.com\/wp-content\/uploads\/2026\/07\/SEI_305085506.jpg 1350w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2026\/07\/SEI_305085506.jpg?resize=150,100 150w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2026\/07\/SEI_305085506.jpg?resize=300,200 300w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2026\/07\/SEI_305085506.jpg?resize=768,512 768w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2026\/07\/SEI_305085506.jpg?resize=600,400 600w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2026\/07\/SEI_305085506.jpg?resize=400,267 400w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2026\/07\/SEI_305085506.jpg?resize=900,600 900w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2026\/07\/SEI_305085506.jpg?resize=1200,800 1200w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2026\/07\/SEI_305085506.jpg?resize=196,131 196w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2026\/07\/SEI_305085506.jpg?resize=301,201 301w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2026\/07\/SEI_305085506.jpg?resize=415,277 415w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2026\/07\/SEI_305085506.jpg?resize=602,401 602w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2026\/07\/SEI_305085506.jpg?resize=830,553 830w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2026\/07\/SEI_305085506.jpg?resize=105,70 105w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2026\/07\/SEI_305085506.jpg?resize=210,140 210w\" sizes=\"(max-width: 1350px) 100vw, 1350px\"><figcaption class=\"wp-element-caption\"><div class=\"wp-image__caption--icon\"><svg width=\"15\" height=\"15\" viewbox=\"0 0 15 15\"><use href=\"https:\/\/www.newscientist.com\/wp-content\/themes\/newscientist\/images\/icon-circle-chevron.svg#icon-circle-chevron\"><\/use><\/svg><\/div><div class=\"wp-image__caption--text\">Beta-amyloid forms plaques in the brain (seen in yellow) that play a role in Alzheimer\u2019s disease<\/div><div class=\"wp-image__caption--credit\">JUAN GAERTNER\/SCIENCE PHOTO LIBRARY\/Alamy<\/div><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">A cognitive \u201cspeed training\u201d game that cuts dementia risk by 25 per cent alters levels of beta-amyloid, a protein that clogs up the brain in Alzheimer\u2019s disease, in men, but not in women.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It is the first time brain training has been shown to influence the levels of a neurodegenerative marker, strengthening the evidence suggesting that mental exercises can boost brain health.<\/p>\n\n\n\n\t<div class=\"read-more__standard wp-block-newscientist-read-more\">\n\t\t<a class=\"read-more__standard--wrapper no-animation\" href=\"https:\/\/www.newscientist.com\/article\/2491017-chronic-inflammation-messes-with-your-mind-heres-how-to-calm-it\/\">\n\t\t\t<strong>Read more<\/strong>\n\t\t\t<p>Chronic inflammation messes with your mind. Here\u2019s how to calm it<\/p>\n\t\t<\/a>\n\t<\/div>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cOne of the main markers that\u2019s indicative of future dementia risk got better for men who completed cognitive speed training,\u201d says\u00a0<a href=\"https:\/\/eur02.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.clemson.edu%2Fcbshs%2Fabout%2Fprofiles%2Findex.html%3Fuserid%3Dhchai&amp;data=05%7C02%7CCarissa.Wong%40newscientist.com%7C2db4b866739646df863208dee0bb0183%7C0f3a4c644dc54a768d4152d85ca158a5%7C0%7C0%7C639195290943700151%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&amp;sdata=mxFXcVrABFgQMw63wcyv9R%2F8v0GAZ7mPVTwwEh7N3HE%3D&amp;reserved=0\">Hye Won Chai<\/a>\u00a0at Clemson University in South Carolina, who presented the research at the Alzheimer\u2019s Association International Conference in London on 12 July.<\/p>\n<div class=\"advert-wrapper advert__mid-article\">\n\t<div class=\"advert\">\n\t\t<div class=\"advert__inner\">\n\t\t\t\t\t\t\t<p class=\"advert__copy\">\n\t\t\t\t\tAdvertisement\t\t\t\t<\/p>\n\t\t\t\t\t\t<div class=\"advert__slot\" id=\"mid-article-slot\">\n\t\t\t\t<script>\n\t\t\t\t\tif( window?.adverts?.addToArray ) {\n\t\t\t\t\t\twindow.adverts.addToArray( {\n\t\t\t\t\t\t\t\"pos\": \"mid-article-slot\"\n\t\t\t\t\t\t} );\n\t\t\t\t\t}\n\t\t\t\t<\/script>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n\n<p class=\"wp-block-paragraph\">The computer-based speed training involves recalling where objects have flashed up, with the task becoming harder as performance improves. A prior 20-year study by some of Chai\u2019s colleagues showed that people aged 65 and older, who did the training were\u00a0<a href=\"https:\/\/www.newscientist.com\/article\/2514823-specific-cognitive-training-has-astonishing-effect-on-dementia-risk\/\">25 per cent less likely to be diagnosed with Alzheimer\u2019s disease<\/a>\u00a0or a related form of dementia compared with a control group.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In the latest study, Chai and her team recruited a separate group of 53 people from the US aged 65 and older, 13 of whom were male. About a third of the participants were asked to complete between 2 and 4 hours of speed training each week for 4.5 months.<\/p>\n\n\n\n<div class=\"wp-block-newscientist-newsletter-promotion\">\n\t<div class=\"newsletter-promotion__content\">\n\t\t<p class=\"newsletter-promotion__tagline\">Free newsletter<\/p>\n\t\t<h4 class=\"newsletter-promotion__title\">\n\t\t\tSign up to Health Check\t\t<\/h4>\n\t\t<p class=\"newsletter-promotion__excerpt\">\n\t\t\t\t\t<\/p>\n\t\t<div class=\"newsletter-promotion__actions\">\n\t\t\t<a class=\"button button--secondary button--has-icon\" href=\"https:\/\/www.newscientist.com\/sign-up\/health\/\">\n\t\t\t\t<span>Sign up to newsletter<\/span>\n\t\t\t\t<svg width=\"18\" height=\"18\" viewbox=\"0 0 24 24\" style=\"--fill-color: #000\">\n\t\t\t\t\t<use href=\"https:\/\/www.newscientist.com\/wp-content\/themes\/newscientist\/images\/icon-arrow-right.svg#icon-arrow-right\"><\/use>\n\t\t\t\t<\/svg>\n\t\t\t<\/a>\n\t\t<\/div>\n\t<\/div>\n\t<div class=\"newsletter-promotion__background\">\n\t\t<span class=\"newsletter-promotion__gradient\"><\/span>\n\t\t<div class=\"newsletter-promotion__image__wrapper\">\n\t\t\t<div class=\"image__wrapper\">\n\t\t\t\t<img decoding=\"async\" width=\"600\" height=\"450\" src=\"https:\/\/www.newscientist.com\/wp-content\/uploads\/2025\/06\/16102046\/health_check_2025_ed_newsletter_landingtiles_2400px10.jpg?w=600&amp;h=450&amp;crop=1\" class=\"attachment-4x3-sm size-4x3-sm wp-post-image\" alt=\"\" sizes=\"(min-width: 432px) 412px, (min-width: 300px) 373px, 100vw\" srcset=\"https:\/\/www.newscientist.com\/wp-content\/uploads\/2025\/06\/16102046\/health_check_2025_ed_newsletter_landingtiles_2400px10.jpg?resize=300,225 300w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2025\/06\/16102046\/health_check_2025_ed_newsletter_landingtiles_2400px10.jpg?resize=400,300 400w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2025\/06\/16102046\/health_check_2025_ed_newsletter_landingtiles_2400px10.jpg?resize=600,450 600w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2025\/06\/16102046\/health_check_2025_ed_newsletter_landingtiles_2400px10.jpg?resize=800,600 800w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2025\/06\/16102046\/health_check_2025_ed_newsletter_landingtiles_2400px10.jpg?resize=1024,768 1024w, https:\/\/www.newscientist.com\/wp-content\/uploads\/2025\/06\/16102046\/health_check_2025_ed_newsletter_landingtiles_2400px10.jpg?resize=1920,1440 1920w\">\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\">The remaining participants were either told to spend the same amount of time playing games such as Solitaire, word search and a game similar to Connect 4, or to complete another kind of brain training in which they had to strategically track objects and switch between tasks.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To explore how speed training may reduce dementia risk, the team collected blood samples from all of the participants at the start and end of the training period.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This revealed that, among men, speed training increased the ratio of two forms of beta-amyloid found in the blood, which suggests the training boosted the brain\u2019s ability to clear beta-amyloid 42. This protein forms clumps called plaques in the brain during Alzheimer\u2019s disease, disrupting brain function. The other two kinds of training had no effect.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cIt\u2019s a really cool finding,\u201d says\u00a0<a href=\"https:\/\/eur02.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fnist.mni.mcgill.ca%2Fsasha-novozhilova%2F&amp;data=05%7C02%7CCarissa.Wong%40newscientist.com%7C2db4b866739646df863208dee0bb0183%7C0f3a4c644dc54a768d4152d85ca158a5%7C0%7C0%7C639195290943745657%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&amp;sdata=i6%2B7OriDkRxt2710ygITI9YJ4mhJyc0A8yPiQxl9wuw%3D&amp;reserved=0\">Sasha Novozhilova<\/a>\u00a0at McGill University in Montreal. \u201cIt is definitely strengthening what they\u2019ve [previously] shown with the reduction in dementia.\u201d<\/p>\n\n\n\n\t<div class=\"read-more__standard wp-block-newscientist-read-more\">\n\t\t<a class=\"read-more__standard--wrapper no-animation\" href=\"https:\/\/www.newscientist.com\/article\/2479542-why-honing-your-sense-of-smell-could-keep-you-sharp-as-you-age\/\">\n\t\t\t<strong>Read more<\/strong>\n\t\t\t<p>Why honing your sense of smell could keep you sharp as you age<\/p>\n\t\t<\/a>\n\t<\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Some Alzheimer\u2019s treatments, such as lecanemab, have been designed to help clear amyloid from the brain, but they only marginally slow cognitive decline during Alzheimer\u2019s disease. The limited benefit seen in trials is probably down to these treatments being taken at a relatively late stage of the condition, when substantial brain damage has already occurred, says <a href=\"https:\/\/profiles.ucl.ac.uk\/56038-andrea-castegnaro\">Andrea Castegnaro<\/a> at University College London.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Engaging in cognitive training to reduce beta-amyloid build-up before dementia develops may have a bigger effect on dementia because it would be done before much brain damage has occurred, says Castegnaro.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, cognitive training had no effect on amyloid levels in female participants in the study. This suggests that speed training reduces dementia risk in different ways in women and men, says Chai.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The team hopes to explore how speed training may benefit women in future studies, says Chai. But first, the findings need to be verified in geographically and ethnically diverse groups, says Novozhilova.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Playing a mental speed-training game seems to help the brain clear a protein linked to Alzheimer\u2019s disease in men, but may work in women through different mechanisms<\/p>\n","protected":false},"author":881,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1191,3443,1163,2429,64],"tags":[],"class_list":["post-62517","post","type-post","status-publish","format-standard","hentry","category-alzheimers","category-alzheimers-disease-and-dementia","category-brain","category-dementia","category-health"],"_links":{"self":[{"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/posts\/62517"}],"collection":[{"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/users\/881"}],"replies":[{"embeddable":true,"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/comments?post=62517"}],"version-history":[{"count":2,"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/posts\/62517\/revisions"}],"predecessor-version":[{"id":62576,"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/posts\/62517\/revisions\/62576"}],"wp:attachment":[{"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/media?parent=62517"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/categories?post=62517"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/tags?post=62517"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}