{"id":7851,"date":"2016-05-24T00:40:07","date_gmt":"2016-05-24T00:40:07","guid":{"rendered":"http:\/\/www.kurzweilai.net\/?p=280834"},"modified":"2016-05-27T00:34:02","modified_gmt":"2016-05-27T00:34:02","slug":"transistor-based-biosensor-detects-molecules-linked-to-cancer-alzheimers-and-parkinsons","status":"publish","type":"post","link":"https:\/\/hoo.central12.com\/fugic\/2016\/05\/24\/transistor-based-biosensor-detects-molecules-linked-to-cancer-alzheimers-and-parkinsons\/","title":{"rendered":"Transistor-based biosensor detects molecules linked to cancer, Alzheimer’s, and Parkinson’s"},"content":{"rendered":"
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An inexpensive portable biosensor developed by researchers at Brazil’s National Nanotechnology Laboratory (credit: LNNano)<\/p><\/div>\n

A novel nanoscale organic transistor-based biosensor that can detect molecules associated with neurodegenerative diseases and some types of cancer has been developed by researchers at the National Nanotechnology Laboratory (LNNano)<\/a> in Brazil.<\/p>\n

The transistor, mounted on a glass slide, contains the reduced form of the peptide glutathione (GSH), which reacts in a specific way when it comes into contact with the enzyme glutathione S-transferase (GST), linked to Parkinson\u2019s, Alzheimer\u2019s and breast cancer, among other diseases.<\/p>\n

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Sensitive water-gated copper phthalocyanine (CuPc) thin-film transistor (credit: Rafael Furlan de Oliveira et al.\/Organic Electronics)<\/p><\/div>\n

“The device can detect such molecules even when they\u2019re present at very low levels in the examined material, thanks to its nanometric sensitivity,\u201d explained Carlos Cesar Bof Bufon, Head of LNNano\u2019s Functional Devices & Systems Lab (DSF).<\/p>\n

Bufon said the system can be adapted to detect other substances by replacing the analytes (detection compounds). The team is working on paper-based biosensors to further lower the cost, improve portability, and facilitate fabrication and disposal.<\/p>\n

The research is published in the journal\u00a0Organic Electronics<\/em><\/strong>.<\/p>\n

\n

Abstract of\u00a0Water-gated phthalocyanine transistors: Operation and transduction of the peptide\u2013enzyme interaction<\/em><\/h4>\n

The use of aqueous solutions as the gate medium is an attractive strategy to obtain high charge carrier density (1012<\/sup>\u00a0cm\u22122<\/sup>) and low operational voltages (<1\u00a0V) in organic transistors. Additionally, it provides a simple and favorable architecture to couple both ionic and electronic domains in a single device, which is crucial for the development of novel technologies in bioelectronics. Here, we demonstrate the operation of transistors containing copper phthalocyanine (CuPc) thin-films gated with water and discuss the charge dynamics at the CuPc\/water interface. Without the need for complex multilayer patterning, or the use of surface treatments, water-gated CuPc transistors exhibited low threshold (100\u00a0\u00b1\u00a020\u00a0mV) and working voltages (<1\u00a0V) compared to conventional CuPc transistors, along with similar charge carrier mobilities (1.2\u00a0\u00b1\u00a00.2) x 10\u22123<\/sup>\u00a0cm2<\/sup>\u00a0V\u22121<\/sup>\u00a0s\u22121<\/sup>. Several device characteristics such as moderate switching speeds and hysteresis, associated with high capacitances at low frequencies upon bias application (3.4\u201312\u00a0\u03bcF\u00a0cm\u22122<\/sup>), indicate the occurrence of interfacial ion doping. Finally, water-gated CuPc OTFTs were employed in the transduction of the biospecific interaction between tripeptide reduced glutathione (GSH) and glutathione S-transferase (GST) enzyme, taking advantage of the device sensitivity and multiparametricity.<\/p>\n","protected":false},"excerpt":{"rendered":"

A novel nanoscale organic transistor-based biosensor that can detect molecules associated with neurodegenerative diseases and some types of cancer has been developed by researchers at the National Nanotechnology Laboratory (LNNano) in Brazil. The transistor, mounted on a glass slide, contains the reduced form of the peptide glutathione (GSH), which reacts in a specific way when […]<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[45,48,55,43],"tags":[],"class_list":["post-7851","post","type-post","status-publish","format-standard","hentry","category-biomedlongevity","category-electronics","category-nanotechmaterials-science","category-news"],"_links":{"self":[{"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/posts\/7851"}],"collection":[{"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/comments?post=7851"}],"version-history":[{"count":3,"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/posts\/7851\/revisions"}],"predecessor-version":[{"id":7923,"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/posts\/7851\/revisions\/7923"}],"wp:attachment":[{"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/media?parent=7851"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/categories?post=7851"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hoo.central12.com\/fugic\/wp-json\/wp\/v2\/tags?post=7851"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}