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Cinnamon may be the latest nootropic

(credit: The Great American Spice Co.)

Kalipada Pahan, PhD, a researcher at Rush University and the Jesse Brown VA Medical Center in Chicago, has found that cinnamon improved performance of mice in a maze test.

His group published their latest findings online June 24, 2016, in the Journal of Neuroimmune Pharmacology.

“The increase in learning in poor-learning mice after cinnamon treatment was significant,” says Pahan. “For example, poor-learning mice took about 150 seconds to find the right hole in the Barnes maze test. On the other hand, after one month of cinnamon treatment, poor-learning mice were finding the right hole within 60 seconds.”

Acts as slow-release form of sodium benzoate

Pahan’s research shows that the effect appears to be due mainly to sodium benzoate, a chemical produced as cinnamon is broken down in the body. Food makers use a synthetic form of it as a preservative. It is also an FDA-approved drug used to treat hyperammonemia — too much ammonia in the blood.

Though some health concerns exist regarding sodium benzoate, most experts agree it’s perfectly safe in the amounts generally consumed. One reassuring point is that it’s water-soluble and easily excreted in the urine.

Cinnamon acts as a slow-release form of sodium benzoate, says Pahan. His lab studies show that different compounds within cinnamon—including cinnamaldehyde, which gives the spice is distinctive flavor and aroma—are “metabolized into sodium benzoate in the liver. Sodium benzoate then becomes the active compound, which readily enters the brain and stimulates hippocampal plasticity.”

Those changes in the hippocampus—the brain’s main memory center—appear to be the mechanism by which cinnamon and sodium benzoate exert their benefits.

In their study, Pahan’s group first tested mice in mazes to separate the good and poor learners. Good learners made fewer wrong turns and took less time to find food. In analyzing baseline disparities between the good and poor learners, Pahan’s team found differences in two brain proteins. The gap was all but erased when cinnamon was given.

“Little is known about the changes that occur in the brains of poor learners,” says Pahan. “We saw increases in GABRA5 and a decrease in CREB in the hippocampus of poor learners. Interestingly, these particular changes were reversed by one month of cinnamon treatment.”

The researchers also examined brain cells taken from the mice. They found that sodium benzoate enhanced the structural integrity of the dendrites, the tree-like extensions of neurons that enable them to communicate with other brain cells.

High-quality clinical evidence on cinnamon is limited

Cinnamon, like many spices, has antioxidant and anti-inflammatory properties. So it could be expected to exert a range of health-boosting actions, and it does have a centuries-long history of medicinal use around the world.

But the U.S. National Center for Complementary and Integrative Health says that “high-quality clinical evidence to support the use of cinnamon for any medical condition is generally lacking.” Most of the clinical trials that have taken place have focused on the spice’s possible effect on blood sugar for people with diabetes. Little if any clinical research has been done on the spice’s possible brain-boosting properties.

Pahan hopes to change that. Based on the promising results from his group’s preclinical studies, he believes that “besides general memory improvement, cinnamon may target Alzheimer’s disease, mild cognitive impairment [a precursor to Alzheimer's], and Parkinson’s disease as well.” He is now talking with neurologists about planning a clinical trial on Alzheimer’s.

But Pahan warns that most cinnamon found in the store is the Chinese variety, which contains a compound called coumarin that may be toxic to the liver in high amounts. A person would likely have to eat tons of cinnamon to run into a problem, but just the same, Pahan recommends the Ceylon or Sri Lanka type, which is coumarin-free.

“Simply smelling the spice may not help because cinnamaldehyde should be metabolized into cinnamic acid and then sodium benzoate,” explains Pahan. “For metabolism [to occur], cinnamaldehyde should be within the cell.”

As for himself, Pahan isn’t waiting for clinical trials. He takes about a teaspoonful—about 3.5 grams—of cinnamon powder mixed with honey as a supplement every night.

Should the research on cinnamon continue to move forward, he envisions a similar remedy being adopted by struggling students worldwide.

Pahan’s study was funded by VA, the National Institutes of Health, and the Alzheimer’s Association.

Abstract of Cinnamon Converts Poor Learning Mice to Good Learners: Implications for Memory Improvement

This study underlines the importance of cinnamon, a commonly used natural spice and flavoring material, and its metabolite sodium benzoate (NaB) in converting poor learning mice to good learning ones. NaB, but not sodium formate, was found to upregulate plasticity-related molecules, stimulate NMDA- and AMPA-sensitive calcium influx and increase of spine density in cultured hippocampal neurons. NaB induced the activation of CREB in hippocampal neurons via protein kinase A (PKA), which was responsible for the upregulation of plasticity-related molecules. Finally, spatial memory consolidation-induced activation of CREB and expression of different plasticity-related molecules were less in the hippocampus of poor learning mice as compared to good learning ones. However, oral treatment of cinnamon and NaB increased spatial memory consolidation-induced activation of CREB and expression of plasticity-related molecules in the hippocampus of poor-learning mice and converted poor learners into good learners. These results describe a novel property of cinnamon in switching poor learners to good learners via stimulating hippocampal plasticity.

Posted on

Cinnamon may be the latest nootropic

(credit: The Great American Spice Co.)

Kalipada Pahan, PhD, a researcher at Rush University and the Jesse Brown VA Medical Center in Chicago, has found that cinnamon improved performance of mice in a maze test.

His group published their latest findings online June 24, 2016, in the Journal of Neuroimmune Pharmacology.

“The increase in learning in poor-learning mice after cinnamon treatment was significant,” says Pahan. “For example, poor-learning mice took about 150 seconds to find the right hole in the Barnes maze test. On the other hand, after one month of cinnamon treatment, poor-learning mice were finding the right hole within 60 seconds.”

Acts as slow-release form of sodium benzoate

Pahan’s research shows that the effect appears to be due mainly to sodium benzoate, a chemical produced as cinnamon is broken down in the body. Food makers use a synthetic form of it as a preservative. It is also an FDA-approved drug used to treat hyperammonemia — too much ammonia in the blood.

Though some health concerns exist regarding sodium benzoate, most experts agree it’s perfectly safe in the amounts generally consumed. One reassuring point is that it’s water-soluble and easily excreted in the urine.

Cinnamon acts as a slow-release form of sodium benzoate, says Pahan. His lab studies show that different compounds within cinnamon—including cinnamaldehyde, which gives the spice is distinctive flavor and aroma—are “metabolized into sodium benzoate in the liver. Sodium benzoate then becomes the active compound, which readily enters the brain and stimulates hippocampal plasticity.”

Those changes in the hippocampus—the brain’s main memory center—appear to be the mechanism by which cinnamon and sodium benzoate exert their benefits.

In their study, Pahan’s group first tested mice in mazes to separate the good and poor learners. Good learners made fewer wrong turns and took less time to find food. In analyzing baseline disparities between the good and poor learners, Pahan’s team found differences in two brain proteins. The gap was all but erased when cinnamon was given.

“Little is known about the changes that occur in the brains of poor learners,” says Pahan. “We saw increases in GABRA5 and a decrease in CREB in the hippocampus of poor learners. Interestingly, these particular changes were reversed by one month of cinnamon treatment.”

The researchers also examined brain cells taken from the mice. They found that sodium benzoate enhanced the structural integrity of the dendrites, the tree-like extensions of neurons that enable them to communicate with other brain cells.

High-quality clinical evidence on cinnamon is limited

Cinnamon, like many spices, has antioxidant and anti-inflammatory properties. So it could be expected to exert a range of health-boosting actions, and it does have a centuries-long history of medicinal use around the world.

But the U.S. National Center for Complementary and Integrative Health says that “high-quality clinical evidence to support the use of cinnamon for any medical condition is generally lacking.” Most of the clinical trials that have taken place have focused on the spice’s possible effect on blood sugar for people with diabetes. Little if any clinical research has been done on the spice’s possible brain-boosting properties.

Pahan hopes to change that. Based on the promising results from his group’s preclinical studies, he believes that “besides general memory improvement, cinnamon may target Alzheimer’s disease, mild cognitive impairment [a precursor to Alzheimer's], and Parkinson’s disease as well.” He is now talking with neurologists about planning a clinical trial on Alzheimer’s.

But Pahan warns that most cinnamon found in the store is the Chinese variety, which contains a compound called coumarin that may be toxic to the liver in high amounts. A person would likely have to eat tons of cinnamon to run into a problem, but just the same, Pahan recommends the Ceylon or Sri Lanka type, which is coumarin-free.

“Simply smelling the spice may not help because cinnamaldehyde should be metabolized into cinnamic acid and then sodium benzoate,” explains Pahan. “For metabolism [to occur], cinnamaldehyde should be within the cell.”

As for himself, Pahan isn’t waiting for clinical trials. He takes about a teaspoonful—about 3.5 grams—of cinnamon powder mixed with honey as a supplement every night.

Should the research on cinnamon continue to move forward, he envisions a similar remedy being adopted by struggling students worldwide.

Pahan’s study was funded by VA, the National Institutes of Health, and the Alzheimer’s Association.

Abstract of Cinnamon Converts Poor Learning Mice to Good Learners: Implications for Memory Improvement

This study underlines the importance of cinnamon, a commonly used natural spice and flavoring material, and its metabolite sodium benzoate (NaB) in converting poor learning mice to good learning ones. NaB, but not sodium formate, was found to upregulate plasticity-related molecules, stimulate NMDA- and AMPA-sensitive calcium influx and increase of spine density in cultured hippocampal neurons. NaB induced the activation of CREB in hippocampal neurons via protein kinase A (PKA), which was responsible for the upregulation of plasticity-related molecules. Finally, spatial memory consolidation-induced activation of CREB and expression of different plasticity-related molecules were less in the hippocampus of poor learning mice as compared to good learning ones. However, oral treatment of cinnamon and NaB increased spatial memory consolidation-induced activation of CREB and expression of plasticity-related molecules in the hippocampus of poor-learning mice and converted poor learners into good learners. These results describe a novel property of cinnamon in switching poor learners to good learners via stimulating hippocampal plasticity.

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Americans worried about gene editing, brain chip implants, and synthetic blood

(iStock Photo)

Many in the general U.S. public are concerned about technologies to make people’s minds sharper and their bodies stronger and healthier than ever before, according to a new Pew Research Center survey of more than 4,700 U.S. adults.

The survey covers broad public reaction to scientific advances and examines public attitudes about the potential use of three specific emerging technologies for human enhancement.

The nationally representative survey centered on public views about gene editing that might give babies a lifetime with much reduced risk of serious disease, implantation of brain chips that potentially could give people a much improved ability to concentrate and process information, and transfusions of synthetic blood that might give people much greater speed, strength, and stamina.

A majority of Americans would be “very” or “somewhat” worried about gene editing (68%); brain chips (69%); and synthetic blood (63%), while no more than half say they would be enthusiastic about each of these developments.

Among the key data:

  • More say they would not want enhancements of their brains and their blood–66% and 63%, respectively–than say they would want them (32% and 35%). U.S. adults are closely split on the question of whether they would want gene editing to help prevent diseases for their babies (48% would, 50% would not).
  • Majorities say these enhancements could exacerbate the divide between haves and have-nots. For instance, 73% believe inequality will increase if brain chips become available because initially they will be obtainable only by the wealthy. At least seven-in-ten predict each of these technologies will become available before they have been fully tested or understood.
  • Substantial shares say they are not sure whether these interventions are morally acceptable. But among those who express an opinion, more people say brain and blood enhancements would be morally unacceptable than say they are acceptable.
  • More adults say the downsides of brain and blood enhancements would outweigh the benefits for society than vice versa. Americans are a bit more positive about the impact of gene editing to reduce disease; 36% think it will have more benefits than downsides, while 28% think it will have more downsides than benefits.
  • Opinion is closely divided when it comes to the fundamental question of whether these potential developments are “meddling with nature” and cross a line that should not be crossed, or whether they are “no different” from other ways that humans have tried to better themselves over time. For example, 49% of adults say transfusions with synthetic blood for much improved physical abilities would be “meddling with nature,” while a roughly equal share (48%) say this idea is no different than other ways human have tried to better themselves.

The survey data reveal several patterns surrounding Americans’ views about these ideas:

  • People’s views about these human enhancements are strongly linked with their religiosity.
  • People are less accepting of enhancements that produce extreme changes in human abilities. And, if an enhancement is permanent and cannot be undone, people are less inclined to support it.
  • Women tend to be more wary than men about these potential enhancements from cutting-edge technologies.

The survey also finds some similarities between what Americans think about these three potential, future enhancements and their attitudes toward the kinds of enhancements already widely available today. As a point of comparison, this study examined public thinking about a handful of current enhancements, including elective cosmetic surgery, laser eye surgery, skin or lip injections, cosmetic dental procedures to improve one’s smile, hair replacement surgery and contraceptive surgery.

  • 61% of Americans say people are too quick to undergo cosmetic procedures to change their appearance in ways that are not really important, while 36% “it’s understandable that more people undergo cosmetic procedures these days because it’s a competitive world and people who look more attractive tend to have an advantage.”
  • When it comes to views about elective cosmetic surgery, in particular, 34% say elective cosmetic surgery is “taking technology too far,” while 62% say it is an “appropriate use of technology.” Some 54% of U.S. adults say elective cosmetic surgery leads to about equal benefits and downsides for society, while 26% express the belief that there are more downsides than benefits, and just 16% say society receives more benefits than downsides from cosmetic surgery.

The survey data is drawn from a nationally representative survey of 4,726 U.S. adults conducted by Pew Research Center online and by mail from March 2-28, 2016.

Pew Research Center is a nonpartisan “fact tank” that informs the public about the issues, attitudes and trends shaping America and the world. It does not take policy positions. The center is a subsidiary of The Pew Charitable Trusts, its primary funder.